Proteoglycan 4

PRG4
Identifiers
Aliases	PRG4, CACP, HAPO, JCAP, MSF, SZP, bG174L6.2, proteoglycan 4
External IDs	OMIM: 604283; MGI: 1891344; HomoloGene: 130465; GeneCards: PRG4; OMA:PRG4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	186,314,567 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	150,466,165 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; Achilles tendon; ; pericardium; ; synovial membrane; ; parietal pleura; ; right lobe of liver; ; germinal epithelium; ; islet of Langerhans; ; popliteal artery; ; tibial arteries;
	Top expressed in
	ankle; ; tibiofemoral joint; ; trachea; ; intercostal muscle; ; stroma of bone marrow; ; semi-lunar valve; ; aortic valve; ; muscle of thigh; ; left lobe of liver; ; medial head of gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; polysaccharide binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular region; extracellular matrix; collagen-containing extracellular matrix;
Biological process	cell population proliferation; receptor-mediated endocytosis; immune response; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	10216
	96875
	ENSG00000116690
	ENSMUSG00000006014
	Q92954
	Q9JM99
	NM_005807; NM_001127708; NM_001127709; NM_001127710; NM_001303232
	NM_001110146; NM_021400
	NP_001121180; NP_001121181; NP_001121182; NP_001290161; NP_005798
	NP_001103616; NP_067375
	Wikidata
View/Edit Human	View/Edit Mouse

Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. It acts as a joint/boundary lubricant.