PRKAB1

PRKAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV
Identifiers
Aliases	PRKAB1, AMPK, HAMPKb, protein kinase AMP-activated non-catalytic subunit beta 1
External IDs	OMIM: 602740; MGI: 1336167; HomoloGene: 38160; GeneCards: PRKAB1; OMA:PRKAB1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	119,681,624 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	116,162,567 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; human kidney; ; body of stomach; ; spleen; ; renal medulla; ; upper lobe of left lung; ; body of pancreas; ; right lung;
	Top expressed in
	granulocyte; ; neural layer of retina; ; yolk sac; ; secondary oocyte; ; medullary collecting duct; ; fetal liver hematopoietic progenitor cell; ; transitional epithelium of urinary bladder; ; zygote; ; primary oocyte; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; AMP-activated protein kinase activity; protein binding; protein kinase binding; kinase activity;
Cellular component	cytosol; nucleotide-activated protein kinase complex; nucleus; nucleoplasm; protein-containing complex; cytoplasm;
Biological process	protein heterooligomerization; lipid metabolism; fatty acid metabolic process; protein phosphorylation; positive regulation of gene expression; fatty acid biosynthetic process; regulation of catalytic activity; macroautophagy; nail development; signal transduction; positive regulation of cold-induced thermogenesis; regulation of macroautophagy; regulation of signal transduction by p53 class mediator; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5564
	19079
	ENSG00000111725
	ENSMUSG00000029513
	Q9Y478
	Q9R078
	NM_006253
	NM_031869
	NP_006244; NP_006244.2
	NP_114075
	Wikidata
View/Edit Human	View/Edit Mouse

5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.