PRKACA

PRKACA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6, 4AE9, 4WB5, 4WB6, 4WB7, 4WB8, 5IZJ, 4UJB, 4UJA, 4UJ2, 4UJ1, 4UJ9
Identifiers
Aliases	PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1
External IDs	OMIM: 601639; MGI: 97592; HomoloGene: 121574; GeneCards: PRKACA; OMA:PRKACA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,118,084 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,723,072 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; apex of heart; ; left ventricle; ; right auricle of heart; ; skeletal muscle tissue; ; muscle of thigh; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; smooth muscle tissue;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; dorsomedial hypothalamic nucleus; ; entorhinal cortex; ; perirhinal cortex; ; superior frontal gyrus; ; primary visual cortex; ; brown adipose tissue; ; muscle of thigh; ; Medulla Oblongata; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; ATP binding; protein kinase activity; transferase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; nucleotide binding; ubiquitin protein ligase binding; cAMP-dependent protein kinase activity; magnesium ion binding; protein serine/threonine kinase activity; protein domain specific binding; manganese ion binding; protein kinase A regulatory subunit binding;
Cellular component	calcium channel complex; membrane; mitochondrion; nucleus; centrosome; cell projection; nuclear speck; cilium; motile cilium; extracellular exosome; plasma membrane; nucleoplasm; nucleotide-activated protein kinase complex; sperm midpiece; plasma membrane raft; acrosomal vesicle; cytoplasm; cytosol; cytoplasmic vesicle; intercellular bridge; perinuclear region of cytoplasm; neuromuscular junction; sperm flagellum; dendritic spine; ciliary base; cAMP-dependent protein kinase complex; axoneme;
Biological process	activation of protein kinase A activity; regulation of bicellular tight junction assembly; cellular response to epinephrine stimulus; protein phosphorylation; regulation of osteoblast differentiation; G2/M transition of mitotic cell cycle; cellular response to glucose stimulus; regulation of cytosolic calcium ion concentration; stimulatory C-type lectin receptor signaling pathway; phosphorylation; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; cellular response to glucagon stimulus; mRNA processing; regulation of heart rate; calcium-mediated signaling using intracellular calcium source; regulation of proteasomal protein catabolic process; regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac conduction; cell communication by electrical coupling involved in cardiac conduction; blood coagulation; renal water homeostasis; regulation of cardiac muscle contraction; regulation of protein binding; regulation of macroautophagy; cellular response to heat; ciliary basal body-plasma membrane docking; mesoderm formation; neural tube closure; peptidyl-threonine phosphorylation; protein autophosphorylation; positive regulation of protein export from nucleus; sperm capacitation; modulation of chemical synaptic transmission; regulation of protein processing; cellular response to parathyroid hormone stimulus; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; peptidyl-serine phosphorylation; high-density lipoprotein particle assembly; regulation of G2/M transition of mitotic cell cycle; protein kinase A signaling; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5566
	18747
	ENSG00000072062; ENSG00000288516
	ENSMUSG00000005469
	P17612
	P05132
	NM_207518; NM_001304349; NM_002730
	NM_001277898; NM_008854
	NP_001291278; NP_002721; NP_997401
	NP_001264827; NP_032880
	Wikidata
View/Edit Human	View/Edit Mouse

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.