PRKAR2A

PRKAR2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IZX, 2KYG, 4ZP3
Identifiers
Aliases	PRKAR2A, PKR2, PRKAR2, protein kinase cAMP-dependent type II regulatory subunit alpha
External IDs	OMIM: 176910; MGI: 108025; HomoloGene: 3064; GeneCards: PRKAR2A; OMA:PRKAR2A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,847,874 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,627,635 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; oocyte; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; olfactory bulb; ; Skeletal muscle tissue of biceps brachii; ; endothelial cell; ; deltoid muscle; ; tendon of biceps brachii; ; tibialis anterior muscle;
	Top expressed in
	habenula; ; Paneth cell; ; ankle; ; triceps brachii muscle; ; migratory enteric neural crest cell; ; hair follicle; ; retinal pigment epithelium; ; sternocleidomastoid muscle; ; digastric muscle; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase A catalytic subunit binding; cAMP binding; protein binding; cAMP-dependent protein kinase regulator activity; cAMP-dependent protein kinase inhibitor activity; ubiquitin protein ligase binding; protein domain specific binding; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytoplasm; cytosol; centrosome; membrane; focal adhesion; plasma membrane raft; plasma membrane; ciliary base; nucleotide-activated protein kinase complex; extracellular exosome; axoneme; cAMP-dependent protein kinase complex; protein-containing complex;
Biological process	regulation of protein phosphorylation; activation of protein kinase A activity; intracellular signal transduction; cellular response to glucagon stimulus; blood coagulation; negative regulation of cAMP-dependent protein kinase activity; renal water homeostasis; cGMP-mediated signaling; binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	5576
	19087
	ENSG00000114302
	ENSMUSG00000032601
	P13861
	P12367
	NM_004157; NM_001321982; NM_001321983; NM_001321989
	NM_008924
	NP_001308911; NP_001308912; NP_001308918; NP_004148
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.