PRKCQ

PRKCQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XJD, 2ENJ, 2ENN, 2ENZ, 2JED, 4Q9Z, 4RA5, 5F9E
Identifiers
Aliases	PRKCQ, PRKCT, nPKC-theta, protein kinase C theta
External IDs	OMIM: 600448; MGI: 97601; HomoloGene: 21263; GeneCards: PRKCQ; OMA:PRKCQ - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	6,580,301 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	11,306,033 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; glutes; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; deltoid muscle; ; muscle of thigh; ; tibialis anterior muscle;
	Top expressed in
	habenula; ; ankle; ; temporal muscle; ; retinal pigment epithelium; ; sternocleidomastoid muscle; ; digastric muscle; ; Epithelium of choroid plexus; ; muscle of thigh; ; seminiferous tubule; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase C activity; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; protein kinase activity;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; intracellular anatomical structure; immunological synapse; microtubule organizing center; aggresome;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; positive regulation of telomere capping; phosphorylation; immune system process; positive regulation of telomere maintenance via telomerase; positive regulation of T-helper 2 cell activation; positive regulation of interleukin-4 production; axon guidance; platelet activation; Fc-epsilon receptor signaling pathway; protein phosphorylation; negative regulation of T cell apoptotic process; negative regulation of insulin receptor signaling pathway; positive regulation of T cell activation; membrane protein ectodomain proteolysis; positive regulation of NF-kappaB transcription factor activity; peptidyl-serine phosphorylation; positive regulation of T-helper 17 type immune response; regulation of cell growth; positive regulation of T cell proliferation; positive regulation of telomerase activity; cell chemotaxis; positive regulation of interleukin-17 production; inflammatory response; T cell receptor signaling pathway; regulation of platelet aggregation; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5588
	18761
	ENSG00000065675
	ENSMUSG00000026778
	Q04759
	Q02111
NM_001242413; NM_001282644; NM_001282645; NM_006257; NM_001323265;
	NM_001323266; NM_001323267
	NM_008859; NM_178075
NP_001229342; NP_001269573; NP_001269574; NP_001310194; NP_001310195;
	NP_001310196; NP_006248
	NP_032885
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene. PKC-θ, a member of serine/threonine kinases, is mainly expressed in hematopoietic cells with high levels in platelets and T lymphocytes, where plays a role in signal transduction. Different subpopulations of T cells vary in their requirements of PKC-θ, therefore PKC-θ is considered as a potential target for inhibitors in the context of immunotherapy.