Protein kinase C zeta type

PRKCZ
Identifiers
Aliases	PRKCZ, PKC-ZETA, PKC2, protein kinase C zeta
External IDs	OMIM: 176982; MGI: 97602; HomoloGene: 55681; GeneCards: PRKCZ; OMA:PRKCZ - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,185,395 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,445,818 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; middle temporal gyrus; ; right frontal lobe; ; pars compacta; ; lateral nuclear group of thalamus; ; Brodmann area 9; ; prefrontal cortex; ; pars reticulata; ; Brodmann area 23; ; primary visual cortex;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; neural layer of retina; ; right kidney; ; primary visual cortex; ; olfactory tubercle; ; nucleus accumbens; ; prefrontal cortex; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; protein domain specific binding; kinase activity; ATP binding; protein kinase activity; metal ion binding; protein serine/threonine kinase activity; insulin receptor substrate binding; transferase activity; 14-3-3 protein binding; potassium channel regulator activity; protein binding; protein kinase binding; nucleotide binding; protein kinase C activity;
Cellular component	cytoplasm; filamentous actin; endosome; nuclear envelope; membrane; cell-cell junction; bicellular tight junction; microtubule organizing center; apical cortex; perinuclear region of cytoplasm; nucleus; nuclear matrix; apical plasma membrane; membrane raft; extracellular exosome; intracellular membrane-bounded organelle; myelin sheath abaxonal region; cell cortex; vesicle; cell junction; cell leading edge; axon hillock; cytosol; plasma membrane; stress fiber; postsynaptic density; protein-containing complex; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	positive regulation of glucose import; insulin receptor signaling pathway; protein heterooligomerization; negative regulation of hydrolase activity; protein kinase C signaling; protein phosphorylation; negative regulation of insulin receptor signaling pathway; cell surface receptor signaling pathway; activation of phospholipase D activity; positive regulation of synaptic transmission; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; transforming growth factor beta receptor signaling pathway; negative regulation of protein-containing complex assembly; negative regulation of peptidyl-tyrosine phosphorylation; establishment of cell polarity; cellular response to insulin stimulus; protein localization to plasma membrane; inflammatory response; phosphorylation; positive regulation of cell-matrix adhesion; membrane depolarization; negative regulation of apoptotic process; positive regulation of interleukin-4 production; positive regulation of protein transport; positive regulation of NF-kappaB transcription factor activity; positive regulation of insulin receptor signaling pathway; positive regulation of T-helper 2 cell cytokine production; microtubule cytoskeleton organization; actin cytoskeleton reorganization; activation of protein kinase B activity; membrane hyperpolarization; vesicle transport along microtubule; neuron projection extension; long-term memory; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; positive regulation of T-helper 2 cell differentiation; cell migration; signal transduction; long-term potentiation; intracellular signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;
	Sources:Amigo / QuickGO
Orthologs
	5590
	18762
	ENSG00000067606
	ENSMUSG00000029053
	Q05513
	Q02956
NM_001033581; NM_001033582; NM_001242874; NM_002744; NM_001350803;
	NM_001350804; NM_001350805; NM_001350806
	NM_001039079; NM_008860; NM_001355178
NP_001028753; NP_001028754; NP_001229803; NP_002735; NP_001337732;
	NP_001337733; NP_001337734; NP_001337735
	NP_001034168; NP_032886; NP_001342107
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. The importance of PKCζ in the creation and maintenance of long-term potentiation was first described by Todd Sacktor and his colleagues at the SUNY Downstate Medical Center in 1993.