Protein kinase D1

PRKD1
Identifiers
Aliases	PRKD1, PKC-MU, PKCM, PKD, PRKCM, Protein kinase D1, CHDED
External IDs	OMIM: 605435; MGI: 99879; HomoloGene: 55680; GeneCards: PRKD1; OMA:PRKD1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	30,191,898 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	50,649,098 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; seminal vesicula; ; thoracic aorta; ; ascending aorta; ; testicle; ; saphenous vein; ; Descending thoracic aorta; ; right coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	primitive streak; ; substantia nigra; ; external carotid artery; ; internal carotid artery; ; fossa; ; primary oocyte; ; condyle; ; renal corpuscle; ; epithelium of lens; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase C activity; metal ion binding; kinase activity; protein binding; identical protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	Golgi apparatus; membrane; plasma membrane; integral component of plasma membrane; autophagosome membrane; cytoplasm; trans-Golgi network; cytosol;
Biological process	negative regulation of endocytosis; cell differentiation; intracellular signal transduction; positive regulation of endothelial cell proliferation; regulation of protein stability; Golgi organization; phosphorylation; immune system process; positive regulation of endothelial cell chemotaxis; protein kinase D signaling; sphingolipid biosynthetic process; negative regulation of cell death; nervous system development; positive regulation of peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of endothelial cell migration; protein phosphorylation; positive regulation of histone deacetylase activity; positive regulation of CREB transcription factor activity; vascular endothelial growth factor receptor signaling pathway; regulation of integrin-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of neuron projection development; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; integrin-mediated signaling pathway; protein autophosphorylation; cellular response to oxidative stress; cellular response to vascular endothelial growth factor stimulus; Ras protein signal transduction; cell population proliferation; inflammatory response; innate immune response; signal transduction; positive regulation of transcription by RNA polymerase II; apoptotic process; positive regulation of autophagy; cellular response to amino acid starvation; positive regulation of phosphatidylinositol 3-kinase activity; cellular response to hydroperoxide; regulation of keratinocyte proliferation; positive regulation of osteoblast differentiation; Golgi vesicle transport; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5587
	18760
	ENSG00000184304
	ENSMUSG00000002688
	Q15139
	Q62101
	NM_002742; NM_001330069; NM_001348390
	NM_008858
	NP_001316998; NP_002733; NP_001335319
	NP_032884; NP_001369743; NP_001369744; NP_001369745
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.