PRMT1

PRMT1
Identifiers
Aliases	PRMT1, ANM1, HCP1, HRMT1L2, IR1B4, protein arginine methyltransferase 1
External IDs	OMIM: 602950; MGI: 107846; HomoloGene: 21477; GeneCards: PRMT1; OMA:PRMT1 - orthologs
EC number	2.1.1.321
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,689,029 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,635,992 bp
RNA expression pattern
	Top expressed in
	embryo; ; right uterine tube; ; ganglionic eminence; ; anterior pituitary; ; body of uterus; ; canal of the cervix; ; muscle of thigh; ; right hemisphere of cerebellum; ; left uterine tube; ; right ovary;
	Top expressed in
	abdominal wall; ; mandibular prominence; ; ventricular zone; ; maxillary prominence; ; medial ganglionic eminence; ; hand; ; yolk sac; ; somite; ; dermis; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; histone methyltransferase activity; transferase activity; histone methyltransferase activity (H4-R3 specific); methyl-CpG binding; mitogen-activated protein kinase p38 binding; protein binding; identical protein binding; enzyme binding; N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; RNA binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; histone-arginine N-methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; S-adenosyl-L-methionine binding;
Cellular component	cytoplasm; nucleoplasm; methylosome; nucleus; cytosol;
Biological process	positive regulation of p38MAPK cascade; positive regulation of hemoglobin biosynthetic process; histone H4-R3 methylation; positive regulation of erythrocyte differentiation; negative regulation of megakaryocyte differentiation; cell surface receptor signaling pathway; methylation; peptidyl-arginine methylation; histone methylation; neuron projection development; peptidyl-arginine N-methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription, DNA-templated; protein methylation; positive regulation of cell population proliferation; regulation of megakaryocyte differentiation; in utero embryonic development; histone arginine methylation; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	3276
	15469
	ENSG00000126457
	ENSMUSG00000109324
	Q99873
	Q9JIF0
	NM_001207042; NM_001536; NM_198318; NM_198319
	NM_001252476; NM_001252477; NM_019830
	NP_001193971; NP_001527; NP_938074
	NP_001239405; NP_001239406; NP_062804
	Wikidata
View/Edit Human	View/Edit Mouse

Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.