Protein arginine methyltransferase 5

PRMT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GQB, 4X60, 4X61, 4X63, 5EML, 5FA5, 5EMJ, 5EMK, 5EMM, 5C9Z
Identifiers
Aliases	PRMT5, HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs, Protein arginine methyltransferase 5, HSL7
External IDs	OMIM: 604045; MGI: 1351645; HomoloGene: 4454; GeneCards: PRMT5; OMA:PRMT5 - orthologs
EC number	2.1.1.321
Gene location (Human)
Chr.	Chromosome 14 (human)
End	22,929,408 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	54,754,982 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; amniotic fluid; ; ganglionic eminence; ; gonad; ; right uterine tube; ; left ovary; ; right ovary; ; gastrocnemius muscle; ; mucosa of transverse colon; ; islet of Langerhans;
	Top expressed in
	tail of embryo; ; epiblast; ; yolk sac; ; maxillary prominence; ; mandibular prominence; ; genital tubercle; ; otic vesicle; ; somite; ; primitive streak; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity (H4-R3 specific); transcription corepressor activity; methyl-CpG binding; core promoter sequence-specific DNA binding; protein binding; protein heterodimerization activity; ribonucleoprotein complex binding; histone-arginine N-methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N symmetric methyltransferase activity; identical protein binding; protein-containing complex binding; E-box binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; nucleoplasm; methylosome; nucleus; histone methyltransferase complex; protein-containing complex;
Biological process	regulation of mitotic nuclear division; positive regulation of oligodendrocyte differentiation; regulation of transcription, DNA-templated; histone H4-R3 methylation; rhythmic process; DNA-templated transcription, termination; negative regulation of cell differentiation; peptidyl-arginine N-methylation; endothelial cell activation; circadian regulation of gene expression; transcription, DNA-templated; spliceosomal snRNP assembly; liver regeneration; methylation; peptidyl-arginine methylation; regulation of ERK1 and ERK2 cascade; regulation of DNA methylation; cell population proliferation; Golgi ribbon formation; protein methylation; negative regulation of nucleic acid-templated transcription; positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of signal transduction by p53 class mediator; peptidyl-arginine methylation, to symmetrical-dimethyl arginine; chromatin organization; histone arginine methylation;
	Sources:Amigo / QuickGO
Orthologs
	10419
	27374
	ENSG00000100462
	ENSMUSG00000023110
	O14744
	Q8CIG8
NM_001039619; NM_001282953; NM_001282954; NM_001282955; NM_001282956;
	NM_006109
	NM_013768; NM_001313906; NM_001313907
NP_001034708; NP_001269882; NP_001269883; NP_001269884; NP_001269885;
	NP_006100
	NP_001300835; NP_001300836; NP_038796
	Wikidata
View/Edit Human	View/Edit Mouse

Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are linked to a range of transcriptional regulatory events.

PRMT5 is a highly conserved arginine methyltransferase that translocated from the cytoplasm to the nucleus at embryonic day ~E8.5, and during preimplantation development at the ~4-cell stage.