PRPF19

PRPF19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LG8
Identifiers
Aliases	PRPF19, NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4, pre-mRNA processing factor 19
External IDs	OMIM: 608330; MGI: 106247; HomoloGene: 6421; GeneCards: PRPF19; OMA:PRPF19 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,906,585 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,886,923 bp
RNA expression pattern
	Top expressed in
	Pons; ; right frontal lobe; ; Brodmann area 9; ; ventricular zone; ; ganglionic eminence; ; prefrontal cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior pituitary; ; islet of Langerhans;
	Top expressed in
	aortic valve; ; primitive streak; ; motor neuron; ; ascending aorta; ; fossa; ; right ventricle; ; epiblast; ; Paneth cell; ; facial motor nucleus; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; protein binding; identical protein binding; transferase activity;
Cellular component	site of double-strand break; nuclear speck; catalytic step 2 spliceosome; membrane; lipid droplet; spindle; Prp19 complex; DNA replication factor A complex; spliceosomal complex; cytoskeleton; nucleus; cytoplasm; nucleoplasm; U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome;
Biological process	mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; lipid biosynthetic process; negative regulation of neuron differentiation; positive regulation of astrocyte differentiation; positive regulation of mRNA splicing, via spliceosome; protein K63-linked ubiquitination; mRNA processing; protein polyubiquitination; inner cell mass cell proliferation; cellular response to DNA damage stimulus; spliceosomal complex assembly; protein ubiquitination; proteasomal protein catabolic process; transcription-coupled nucleotide-excision repair; double-strand break repair via nonhomologous end joining; DNA repair; RNA splicing; generation of catalytic spliceosome for first transesterification step; positive regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	27339
	28000
	ENSG00000110107
	ENSMUSG00000024735
	Q9UMS4
	Q99KP6
	NM_014502
	NM_001253843; NM_001253844; NM_134129
	NP_055317
	NP_001240772; NP_001240773; NP_598890
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.

In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]