PRPF4

PRPF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MZW, 3JCR
Identifiers
Aliases	PRPF4, HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4
External IDs	OMIM: 607795; MGI: 1917302; HomoloGene: 3446; GeneCards: PRPF4; OMA:PRPF4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,294,009 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,345,227 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; corpus epididymis; ; cartilage tissue; ; endothelial cell; ; islet of Langerhans; ; tail of epididymis; ; caput epididymis; ; embryo; ; Skeletal muscle tissue of biceps brachii; ; ventricular zone;
	Top expressed in
	hand; ; maxillary prominence; ; epiblast; ; mandibular prominence; ; foot; ; yolk sac; ; interventricular septum; ; primitive streak; ; cumulus cell; ; superior cervical ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	U4 snRNA binding; protein binding; U6 snRNA binding;
Cellular component	Cajal body; nuclear speck; spliceosomal complex; spliceosomal snRNP complex; U4/U6 snRNP; nucleoplasm; U4/U6 x U5 tri-snRNP complex; nucleus; U2-type precatalytic spliceosome;
Biological process	RNA splicing, via transesterification reactions; mRNA processing; RNA processing; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	9128
	70052
	ENSG00000136875
	ENSMUSG00000066148
	O43172
	Q9DAW6
	NM_001244926; NM_004697; NM_001322266; NM_001322267
	NM_027297
	NP_001231855; NP_001309195; NP_001309196; NP_004688
	NP_081573
	Wikidata
View/Edit Human	View/Edit Mouse

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene.

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.

PRPF4 is 1 of several proteins that associates with U4 and U6 snRNPs.[supplied by OMIM]