PRPF6

PRPF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	PRPF6, ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6, pre-mRNA processing factor 6
External IDs	OMIM: 613979; MGI: 1922946; HomoloGene: 5368; GeneCards: PRPF6; OMA:PRPF6 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,033,100 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,297,453 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; paraflocculus of cerebellum; ; beta cell; ; right hemisphere of cerebellum; ; ganglionic eminence; ; right uterine tube; ; ventricular zone; ; skin of leg; ; Achilles tendon; ; popliteal artery;
	Top expressed in
	supraoptic nucleus; ; aortic valve; ; ascending aorta; ; Rostral migratory stream; ; fossa; ; condyle; ; internal carotid artery; ; external carotid artery; ; zygote; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; protein binding; androgen receptor binding; RNA binding; ribonucleoprotein complex binding;
Cellular component	U4/U6 x U5 tri-snRNP complex; catalytic step 2 spliceosome; membrane; U5 snRNP; spliceosomal complex; nucleus; nucleoplasm; nuclear speck; U2-type precatalytic spliceosome;
Biological process	mRNA splicing, via spliceosome; RNA processing; spliceosomal tri-snRNP complex assembly; RNA splicing, via transesterification reactions; mRNA processing; spliceosomal complex assembly; RNA localization; positive regulation of transcription by RNA polymerase II; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	24148
	68879
	ENSG00000101161
	ENSMUSG00000002455
	O94906
	Q91YR7
	NM_012469
	NM_133701
	NP_036601
	NP_598462
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.