PRPF8

PRPF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E9L, 3ENB, 3LRU, 4JK7, 4JK8, 4JK9, 4JKA, 4JKB, 4JKC, 4JKD, 4JKE, 4JKF, 4JKG, 4JKH, 4KIT, 3JCR
Identifiers
Aliases	PRPF8, pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
External IDs	OMIM: 607300; MGI: 2179381; HomoloGene: 4706; GeneCards: PRPF8; OMA:PRPF8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,684,867 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,400,275 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; ventricular zone; ; bone marrow cells; ; ganglionic eminence; ; left ovary; ; right ovary; ; right hemisphere of cerebellum; ; epithelium of colon; ; right lobe of thyroid gland; ; left testis;
	Top expressed in
	tail of embryo; ; genital tubercle; ; mandibular prominence; ; neural layer of retina; ; epiblast; ; maxillary prominence; ; corneal stroma; ; efferent ductule; ; medial ganglionic eminence; ; primitive streak;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	K63-linked polyubiquitin modification-dependent protein binding; protein binding; RNA binding; second spliceosomal transesterification activity; U6 snRNA binding; U1 snRNA binding; U2 snRNA binding; U5 snRNA binding; pre-mRNA intronic binding;
Cellular component	nuclear speck; catalytic step 2 spliceosome; membrane; U5 snRNP; nucleoplasm; small nuclear ribonucleoprotein complex; spliceosomal complex; nucleus; U4/U6 x U5 tri-snRNP complex; U2-type precatalytic spliceosome; U2-type catalytic step 2 spliceosome;
Biological process	mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; RNA splicing, via transesterification reactions; cellular response to tumor necrosis factor; mRNA processing; RNA splicing; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	10594
	192159
	ENSG00000274442; ENSG00000174231
	ENSMUSG00000020850
	Q6P2Q9
	Q99PV0
	NM_006445
	NM_138659
	NP_006436
	NP_619600
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.