PSCA (gene)

PSCA
Identifiers
Aliases	PSCA, PRO232, prostate stem cell antigen, lncPSCA
External IDs	OMIM: 602470; MGI: 1919623; HomoloGene: 4150; GeneCards: PSCA; OMA:PSCA - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	142,682,725 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	74,588,918 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; olfactory zone of nasal mucosa; ; epithelium of bronchus; ; body of stomach; ; urinary bladder; ; prostate; ; vagina; ; trachea; ; fundus; ; skin of leg;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; transitional epithelium of urinary bladder; ; pyloric antrum; ; gastrula; ; right kidney; ; mucosa of large intestine; ; inner renal medulla; ; urethra; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor binding;
Cellular component	membrane; extracellular exosome; anchored component of membrane; extracellular region; plasma membrane;
Biological process	C-terminal protein lipidation; negative regulation of ERK1 and ERK2 cascade; regulation of neurotransmitter receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8000
	72373
	ENSG00000167653
	ENSMUSG00000022598
	O43653
	P57096
	NM_005672
	NM_028216
	NP_005663
	NP_082492
	Wikidata
View/Edit Human	View/Edit Mouse

Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene.

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene has a nonsynonymous nucleotide polymorphism at its start codon.