Proteasome (prosome, macropain) subunit, alpha 1

PSMA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 1IRU, 5A0Q
Identifiers
Aliases	PSMA1, HC2, HEL-S-275, NU, PROS30, Proteasome (prosome, macropain) subunit, alpha 1, proteasome subunit alpha 1, proteasome 20S subunit alpha 1
External IDs	OMIM: 602854; MGI: 1347005; HomoloGene: 2080; GeneCards: PSMA1; OMA:PSMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,643,635 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	113,875,353 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; smooth muscle tissue; ; lymph node; ; rectum; ; appendix; ; endometrium; ; gastrocnemius muscle; ; Descending thoracic aorta; ; right adrenal cortex; ; monocyte;
	Top expressed in
	otic placode; ; abdominal wall; ; medial ganglionic eminence; ; endocardial cushion; ; mandibular prominence; ; maxillary prominence; ; precursor cell; ; fetal liver hematopoietic progenitor cell; ; migratory enteric neural crest cell; ; efferent ductule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; RNA binding; threonine-type endopeptidase activity; hydrolase activity; lipopolysaccharide binding;
Cellular component	cytoplasm; polysome; cytosol; centrosome; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; immune system process; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; negative regulation of inflammatory response to antigenic stimulus; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5682
	26440
	ENSG00000129084
	ENSMUSG00000030751
	P25786
	Q9R1P4
	NM_148976; NM_001143937; NM_002786
	NM_011965
	NP_001137409; NP_002777; NP_683877
	NP_036095
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-1 is a protein that in humans is encoded by the PSMA1 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, and beta5i) that contributes to the complete assembly of 20S proteasome complex.