PSMA3

PSMA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5DSV, 5A0Q
Identifiers
Aliases	PSMA3, HC8, PSC3, proteasome subunit alpha 3, proteasome 20S subunit alpha 3
External IDs	OMIM: 176843; MGI: 104883; HomoloGene: 2082; GeneCards: PSMA3; OMA:PSMA3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	58,272,012 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	71,043,121 bp
RNA expression pattern
	Top expressed in
	rectum; ; right adrenal gland; ; right adrenal cortex; ; Achilles tendon; ; smooth muscle tissue; ; body of pancreas; ; left adrenal gland; ; right lobe of thyroid gland; ; islet of Langerhans; ; left lobe of thyroid gland;
	Top expressed in
	right kidney; ; embryo; ; embryo; ; ventricular zone; ; blastocyst; ; morula; ; muscle of thigh; ; yolk sac; ; esophagus; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; synapse; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; regulation of endopeptidase activity; viral process; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5684
	19167
	ENSG00000100567
	ENSMUSG00000060073
	P25788
	O70435
	NM_002788; NM_152132
	NM_011184; NM_001310595; NM_001310596
	NP_002779; NP_687033
	NP_001297524; NP_001297525; NP_035314
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.