PSMA4

PSMA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 1IRU, 5A0Q
Identifiers
Aliases	PSMA4, HC9, HsT17706, PSC9, proteasome subunit alpha 4, proteasome 20S subunit alpha 4
External IDs	OMIM: 176846; MGI: 1347060; HomoloGene: 2083; GeneCards: PSMA4; OMA:PSMA4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,552,417 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,865,314 bp
RNA expression pattern
	Top expressed in
	monocyte; ; visceral pleura; ; parietal pleura; ; ganglionic eminence; ; rectum; ; islet of Langerhans; ; ventricular zone; ; right testis; ; palpebral conjunctiva; ; smooth muscle tissue;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; somite; ; medial ganglionic eminence; ; migratory enteric neural crest cell; ; epiblast; ; endocardial cushion; ; atrioventricular valve; ; ventricular zone; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	intracellular membrane-bounded organelle; P-body; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; cytoplasm; cytosol; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5685
	26441
	ENSG00000041357
	ENSMUSG00000032301
	P25789
	Q9R1P0
NM_002789; NM_001102667; NM_001102668; NM_001330673; NM_001330675;
	NM_001330676
	NM_011966
NP_001096137; NP_001096138; NP_001317602; NP_001317604; NP_001317605;
	NP_002780
	NP_036096
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-4 also known as macropain subunit C9, proteasome component C9, and 20S proteasome subunit alpha-3 is a protein that in humans is encoded by the PSMA4 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.