PSMA5

PSMA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 3UNB, 3UNE, 3UNF, 3UNH, 5A0Q
Identifiers
Aliases	PSMA5, PSC5, ZETA, proteasome subunit alpha 5, proteasome 20S subunit alpha 5
External IDs	OMIM: 176844; MGI: 1347009; HomoloGene: 2084; GeneCards: PSMA5; OMA:PSMA5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,426,448 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,187,290 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; mucosa of transverse colon; ; endothelial cell; ; stromal cell of endometrium; ; epithelium of colon; ; rectum; ; granulocyte; ; monocyte; ; right adrenal gland;
	Top expressed in
	embryo; ; embryo; ; epiblast; ; lens; ; blastocyst; ; ventricular zone; ; morula; ; neural tube; ; ganglionic eminence; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	proteasome complex; extracellular exosome; nucleus; proteasome core complex; extracellular region; nucleoplasm; cytoplasm; secretory granule lumen; ficolin-1-rich granule lumen; cytosol; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5686
	26442
	ENSG00000143106
	ENSMUSG00000068749
	P28066
	Q9Z2U1
	NM_002790; NM_001199772; NM_001199773; NM_001199774
	NM_011967
	NP_001186701; NP_001186702; NP_001186703; NP_002781
	NP_036097
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-5 also known as 20S proteasome subunit alpha-5 is a protein that in humans is encoded by the PSMA5 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.