PSMA6

PSMA6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 1IRU, 5A0Q
Identifiers
Aliases	PSMA6, IOTA, PROS27, p27K, proteasome subunit alpha 6, proteasome 20S subunit alpha 6
External IDs	OMIM: 602855; MGI: 1347006; HomoloGene: 2085; GeneCards: PSMA6; OMA:PSMA6 - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	55,465,239 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; islet of Langerhans; ; monocyte; ; gastrocnemius muscle; ; Achilles tendon; ; muscle of thigh; ; placenta; ; endometrium; ; rectum;
	Top expressed in
	Paneth cell; ; internal carotid artery; ; endocardial cushion; ; external carotid artery; ; seminiferous tubule; ; medial ganglionic eminence; ; atrioventricular junction; ; atrioventricular valve; ; endothelial cell of lymphatic vessel; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; NF-kappaB binding; purine ribonucleoside triphosphate binding; peptidase activity; protein binding; RNA binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	polysome; nuclear matrix; P-body; proteasome complex; extracellular exosome; nucleus; proteasome core complex; nucleoplasm; cytoplasm; cytosol; proteasome core complex, alpha-subunit complex; myofibril; sarcomere;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; regulation of inflammatory response; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5687
	26443
	ENSG00000100902
	ENSMUSG00000021024
	P60900
	Q9QUM9
	NM_001282232; NM_001282233; NM_001282234; NM_002791
	NM_011968; NM_001310583
	NP_001269161; NP_001269162; NP_001269163; NP_002782
	NP_001297512; NP_036098
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-6 is a protein that in humans is encoded by the PSMA6 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.