PSMA7

PSMA7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 1IRU, 5A0Q
Identifiers
Aliases	PSMA7, C6, HSPC, RC6-1, XAPC7, HEL-S-276, proteasome subunit alpha 7, proteasome 20S subunit alpha 7
External IDs	OMIM: 606607; MGI: 1347070; HomoloGene: 105299; GeneCards: PSMA7; OMA:PSMA7 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	62,143,440 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,684,226 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; oocyte; ; right adrenal gland; ; left adrenal gland; ; left coronary artery; ; apex of heart; ; right adrenal cortex; ; right lung; ; left adrenal cortex; ; muscle of thigh;
	Top expressed in
	blastocyst; ; embryo; ; embryo; ; endocardial cushion; ; morula; ; ventricular zone; ; maxillary prominence; ; abdominal wall; ; mandibular prominence; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; identical protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; postsynapse; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5688
	26444
	ENSG00000101182
	ENSMUSG00000027566
	O14818
	Q9Z2U0
	NM_152255; NM_002792
	NM_001289476; NM_011969
	NP_002783
	NP_001276405; NP_036099
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-7 also known as 20S proteasome subunit alpha-4 is a protein that in humans is encoded by the PSMA7 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.