PSMB10

PSMB10
Identifiers
Aliases	PSMB10, LMP10, MECL1, beta2i, proteasome subunit beta 10, proteasome 20S subunit beta 10, PRAAS5
External IDs	OMIM: 176847; MGI: 1096380; HomoloGene: 20616; GeneCards: PSMB10; OMA:PSMB10 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,936,864 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,665,076 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; mucosa of transverse colon; ; duodenum; ; putamen; ; appendix; ; substantia nigra; ; apex of heart;
	Top expressed in
	duodenum; ; Ileal epithelium; ; jejunum; ; thymus; ; crypt of lieberkuhn of small intestine; ; embryo; ; colon; ; spleen; ; dentate gyrus of hippocampal formation granule cell; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; nucleus; proteasome core complex; spermatoproteasome complex; proteasome core complex, beta-subunit complex;
Biological process	proteolysis; humoral immune response; proteolysis involved in cellular protein catabolic process; viral process; protein deubiquitination; immune system process; post-translational protein modification; cell morphogenesis; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; T cell proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; MAPK cascade; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of cellular amino acid metabolic process; negative regulation of G2/M transition of mitotic cell cycle; anaphase-promoting complex-dependent catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; tumor necrosis factor-mediated signaling pathway; NIK/NF-kappaB signaling; Fc-epsilon receptor signaling pathway; regulation of mRNA stability; T cell receptor signaling pathway; transmembrane transport; Wnt signaling pathway, planar cell polarity pathway; regulation of transcription from RNA polymerase II promoter in response to hypoxia; interleukin-1-mediated signaling pathway; negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; regulation of mitotic cell cycle phase transition; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5699
	19171
	ENSG00000205220
	ENSMUSG00000031897
	P40306
	O35955
	NM_002801
	NM_013640
	NP_002792
	NP_038668
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene.

This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive beta subunits with inducible beta subunits which possess specific cleavage properties that aid in the release of peptides necessary for MHC class I antigen presentation. The immunoproteasome appears to have a pivotal role in modulating NFκB signaling.