PSMB3

PSMB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB3, HC10-II, proteasome subunit beta 3, proteasome 20S subunit beta 3
External IDs	OMIM: 602176; MGI: 1347014; HomoloGene: 2089; GeneCards: PSMB3; OMA:PSMB3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,604,326 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; bone marrow cells; ; right adrenal gland; ; left adrenal gland; ; renal cortex; ; smooth muscle tissue; ; rectum; ; left ventricle;
	Top expressed in
	Mesencephalon; ; proximal tubule; ; blastocyst; ; neural tube; ; embryo; ; morula; ; right kidney; ; lens; ; embryo; ; limb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytosol; proteasome complex; extracellular exosome; nucleus; proteasome core complex; nucleoplasm; cytoplasm; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5691
	26446
	n/a
	ENSMUSG00000069744
	P49720
	Q9R1P1
	NM_002795
	NM_011971
	NP_002786
	NP_036101
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the PSMB3 gene. This protein is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex. In particular, proteasome subunit beta type-2, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes.