PSMB4

PSMB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB4, HN3, HsN3, PROS-26, PROS26, proteasome subunit beta 4, PRAAS3, proteasome 20S subunit beta 4
External IDs	OMIM: 602177; MGI: 1098257; HomoloGene: 2090; GeneCards: PSMB4; OMA:PSMB4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,401,937 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,794,272 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; right adrenal gland; ; anterior pituitary; ; palpebral conjunctiva; ; gastric mucosa; ; body of uterus; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; smooth muscle tissue;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; epithelium of lens; ; medullary collecting duct; ; endocardial cushion; ; ureter; ; primitive streak; ; Gonadal ridge; ; renal corpuscle; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; lipopolysaccharide binding; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; negative regulation of inflammatory response to antigenic stimulus; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5692
	19172
	ENSG00000159377
	ENSMUSG00000005779
	P28070
	P99026
	NM_002796
	NM_008945
	NP_002787
	NP_032971
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB4 gene.

This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-2, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.