PSMD1

PSMD1
Identifiers
Aliases	PSMD1, P112, Rpn2, S1, proteasome 26S subunit, non-ATPase 1
External IDs	OMIM: 617842; MGI: 1917497; HomoloGene: 2100; GeneCards: PSMD1; OMA:PSMD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	231,173,116 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	86,066,873 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; secondary oocyte; ; gastrocnemius muscle; ; deltoid muscle; ; tibialis anterior muscle; ; glutes; ; Skeletal muscle tissue of rectus abdominis; ; stromal cell of endometrium; ; internal globus pallidus; ; mucosa of transverse colon;
	Top expressed in
	primitive streak; ; facial motor nucleus; ; maxillary prominence; ; ankle; ; endothelial cell of lymphatic vessel; ; anterior horn of spinal cord; ; mandibular prominence; ; hair follicle; ; somite; ; epithelium of lens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; endopeptidase activity; protein binding; ubiquitin protein ligase binding;
Cellular component	cytosol; membrane; proteasome regulatory particle; nucleoplasm; proteasome complex; extracellular exosome; extracellular region; azurophil granule lumen; nucleus; proteasome regulatory particle, base subcomplex; proteasome storage granule; proteasome accessory complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; regulation of protein catabolic process; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of hematopoietic stem cell differentiation; regulation of catalytic activity; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5707
	70247
	ENSG00000173692
	ENSMUSG00000026229
	Q99460
	Q3TXS7
	NM_001191037; NM_002807
	NM_027357
	NP_001177966; NP_002798
	NP_081633
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 1, also as known as 26S Proteasome Regulatory Subunit Rpn2 (systematic nomenclature), is a protein that in humans is encoded by the PSMD1 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.