PSMD10

PSMD10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QYM, 1TR4, 1UOH, 4NIK
Identifiers
Aliases	PSMD10, dJ889N15.2, p28, p28(GANK), proteasome 26S subunit, non-ATPase 10
External IDs	OMIM: 300880; MGI: 1858898; HomoloGene: 94517; GeneCards: PSMD10; OMA:PSMD10 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	108,091,549 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	139,857,477 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; ventricular zone; ; Hypothalamus; ; islet of Langerhans; ; palpebral conjunctiva; ; C1 segment; ; tibia; ; bronchial epithelial cell; ; ganglionic eminence; ; germinal epithelium;
	Top expressed in
	primary oocyte; ; yolk sac; ; right kidney; ; proximal tubule; ; zygote; ; secondary oocyte; ; granulocyte; ; ileum; ; lens; ; neural tube;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; protein binding;
Cellular component	intermediate filament cytoskeleton; cytoplasm; nucleoplasm; proteasome regulatory particle, base subcomplex; nucleus; proteasome regulatory particle; proteasome complex; cytosol;
Biological process	negative regulation of release of cytochrome c from mitochondria; cytoplasmic sequestering of NF-kappaB; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cell growth; negative regulation of transcription by RNA polymerase II; negative regulation of MAPK cascade; negative regulation of DNA damage response, signal transduction by p53 class mediator; proteasome regulatory particle assembly; positive regulation of protein ubiquitination; negative regulation of NF-kappaB transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of apoptotic process; apoptotic process; protein deubiquitination; post-translational protein modification; MAPK cascade; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of cellular amino acid metabolic process; negative regulation of G2/M transition of mitotic cell cycle; anaphase-promoting complex-dependent catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; tumor necrosis factor-mediated signaling pathway; NIK/NF-kappaB signaling; Fc-epsilon receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of mRNA stability; T cell receptor signaling pathway; transmembrane transport; Wnt signaling pathway, planar cell polarity pathway; regulation of transcription from RNA polymerase II promoter in response to hypoxia; interleukin-1-mediated signaling pathway; negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; regulation of mitotic cell cycle phase transition; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5716
	53380
	ENSG00000101843
	ENSMUSG00000031429
	O75832
	Q9Z2X2
	NM_170750; NM_002814
	NM_001164177; NM_016883
	NP_002805; NP_736606
	NP_001157649; NP_058579
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka et al.; Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, both transcription factors involved in tumor suppression and found mutated in many cancers. Gankyrin also has an anti-apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma.