PSMD12

PSMD12
Identifiers
Aliases	PSMD12, Rpn5, p55, proteasome 26S subunit, non-ATPase 12, STISS
External IDs	OMIM: 604450; MGI: 1914247; HomoloGene: 2109; GeneCards: PSMD12; OMA:PSMD12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	67,366,605 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	107,395,188 bp
RNA expression pattern
	Top expressed in
	gonad; ; biceps brachii; ; islet of Langerhans; ; tibialis anterior muscle; ; gastrocnemius muscle; ; right ventricle; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; paraflocculus of cerebellum; ; cerebellar vermis;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; abdominal wall; ; primitive streak; ; tail of embryo; ; genital tubercle; ; atrioventricular valve; ; medial vestibular nucleus; ; digastric muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nuclear proteasome complex; cytosol; membrane; proteasome accessory complex; proteasome regulatory particle; nucleoplasm; proteasome regulatory particle, lid subcomplex; proteasome complex; extracellular exosome; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5718
	66997
	ENSG00000197170
	ENSMUSG00000020720
	O00232
	Q9D8W5
	NM_002816; NM_174871; NM_001316341
	NM_025894
	NP_001303270; NP_002807; NP_777360
	NP_080170
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 12 is an enzyme that in humans is encoded by the PSMD12 gene.