PSMD2

PSMD2
Identifiers
Aliases	PSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
External IDs	OMIM: 606223; MGI: 1096584; HomoloGene: 2101; GeneCards: PSMD2; OMA:PSMD2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,309,050 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,482,164 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; stromal cell of endometrium; ; right testis; ; gastrocnemius muscle; ; left testis; ; muscle of thigh; ; glutes; ; islet of Langerhans; ; right adrenal gland;
	Top expressed in
	yolk sac; ; muscle of thigh; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; genital tubercle; ; blastocyst; ; tail of embryo; ; esophagus; ; spermatocyte; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; protein binding; endopeptidase activity;
Cellular component	cytosol; membrane; nucleoplasm; proteasome complex; extracellular exosome; extracellular region; proteasome regulatory particle; proteasome accessory complex; secretory granule lumen; ficolin-1-rich granule lumen; nucleus; proteasome regulatory particle, base subcomplex; proteasome storage granule;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; regulation of protein catabolic process; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of hematopoietic stem cell differentiation; regulation of catalytic activity; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5708
	21762
	ENSG00000175166
	ENSMUSG00000006998
	Q13200
	Q8VDM4
	NM_002808; NM_001278708; NM_001278709
	NM_134101
	NP_001265637; NP_001265638; NP_002799
	NP_598862
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 2, also as known as 26S Proteasome Regulatory Subunit Rpn1 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD2 gene.