PSMD7

PSMD7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O95, 2O96
Identifiers
Aliases	PSMD7, MOV34, P40, Rpn8, S12, proteasome 26S subunit, non-ATPase 7
External IDs	OMIM: 157970; MGI: 1351511; HomoloGene: 2104; GeneCards: PSMD7; OMA:PSMD7 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	74,306,288 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	108,315,096 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; skin of leg; ; left ventricle; ; skin of abdomen; ; glutes; ; deltoid muscle; ; vastus lateralis muscle; ; monocyte;
	Top expressed in
	muscle of thigh; ; tail of embryo; ; plantaris muscle; ; extensor digitorum longus muscle; ; morula; ; morula; ; temporal muscle; ; yolk sac; ; genital tubercle; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding;
Cellular component	cytosol; membrane; proteasome regulatory particle; nucleoplasm; proteasome complex; extracellular exosome; nucleus; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5713
	17463
	ENSG00000103035
	ENSMUSG00000039067
	P51665
	P26516
	NM_002811
	NM_010817
	NP_002802
	NP_034947
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core consists of 4 rings of 28 non-identical subunits; 2 rings of 7 alpha subunits and 2 rings of 7 beta subunits. The 19S regulator is divided into a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.