PSMD8

PSMD8
Identifiers
Aliases	PSMD8, HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31, proteasome 26S subunit, non-ATPase 8
External IDs	OMIM: 617844; MGI: 1888669; HomoloGene: 37686; GeneCards: PSMD8; OMA:PSMD8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,383,824 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,880,126 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; apex of heart; ; right auricle of heart; ; left ventricle; ; stromal cell of endometrium; ; right testis; ; left testis; ; skin of leg; ; muscle of thigh; ; islet of Langerhans;
	Top expressed in
	seminiferous tubule; ; muscle of thigh; ; triceps brachii muscle; ; lip; ; temporal muscle; ; medial head of gastrocnemius muscle; ; sternocleidomastoid muscle; ; esophagus; ; stroma of bone marrow; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleoplasm; nucleus; proteasome regulatory particle, lid subcomplex; proteasome regulatory particle; proteasome accessory complex; extracellular exosome; cytosol; proteasome complex;
Biological process	NIK/NF-kappaB signaling; proteolysis; MAPK cascade; proteasome assembly; regulation of mRNA stability; protein polyubiquitination; Fc-epsilon receptor signaling pathway; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; tumor necrosis factor-mediated signaling pathway; regulation of protein stability; stimulatory C-type lectin receptor signaling pathway; anaphase-promoting complex-dependent catabolic process; positive regulation of protein targeting to mitochondrion; negative regulation of canonical Wnt signaling pathway; T cell receptor signaling pathway; positive regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5714
	57296
	ENSG00000099341
	ENSMUSG00000030591
	P48556
	Q9CX56
	NM_002812
	NM_026545
	NP_002803
	NP_080821
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 8 is an enzyme that in humans is encoded by the PSMD8 gene.