PSME3

PSME3
Identifiers
Aliases	PSME3, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA, proteasome activator subunit 3
External IDs	OMIM: 605129; MGI: 1096366; HomoloGene: 2111; GeneCards: PSME3; OMA:PSME3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,843,760 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,214,363 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; monocyte; ; stromal cell of endometrium; ; rectum; ; gastrocnemius muscle; ; appendix; ; mucosa of esophagus; ; ganglionic eminence; ; mucosa of transverse colon; ; epithelium of colon;
	Top expressed in
	blood; ; tail of embryo; ; ascending aorta; ; yolk sac; ; aortic valve; ; genital tubercle; ; epiblast; ; ventricular zone; ; spermatocyte; ; seminiferous tubule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	p53 binding; MDM2/MDM4 family protein binding; endopeptidase activator activity; protein binding; identical protein binding;
Cellular component	membrane; proteasome activator complex; nucleoplasm; proteasome complex; nucleus; cytoplasm; cytosol;
Biological process	regulation of proteasomal protein catabolic process; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; regulation of G1/S transition of mitotic cell cycle; NIK/NF-kappaB signaling; cell cycle; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; positive regulation of endopeptidase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	10197
	19192
	ENSG00000131467
	ENSMUSG00000078652
	P61289
	P61290
	NM_001267045; NM_005789; NM_176863; NM_001330229
	NM_011192
	NP_001253974; NP_001317158; NP_005780; NP_789839
	NP_035322
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome activator complex subunit 3 is a protein encoded by the PSME3 gene in humans.