Platelet-activating factor receptor

PTAFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,193,936 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,309,994 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; bone marrow; ; vena cava; ; nasal epithelium; ; pericardium; ; cecum; ; body of tongue; ; bone marrow cells;
	Top expressed in
	granulocyte; ; bone marrow; ; white adipose tissue; ; jejunum; ; esophagus; ; ileum; ; spleen; ; zone of skin; ; urinary bladder; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; G protein-coupled purinergic nucleotide receptor activity; lipopolysaccharide binding; signal transducer activity; mitogen-activated protein kinase binding; platelet activating factor receptor activity; phospholipid binding; lipopolysaccharide immune receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane; tertiary granule membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of leukocyte tethering or rolling; inositol trisphosphate biosynthetic process; positive regulation of voltage-gated chloride channel activity; positive regulation of phospholipase C activity; negative regulation of blood pressure; interferon-gamma-mediated signaling pathway; positive regulation of inositol phosphate biosynthetic process; regulation of transcription by RNA polymerase II; positive regulation of transcytosis; cytokine production; response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; response to symbiotic bacterium; transcytosis; positive regulation of translation; cellular response to gravity; response to dexamethasone; positive regulation of cellular extravasation; positive regulation of maternal process involved in parturition; chemotaxis; cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; positive regulation of sensory perception of pain; response to lipopolysaccharide; cellular response to fatty acid; response to organophosphorus; birth; positive regulation of vasoconstriction; immune response; positive regulation of gastro-intestinal system smooth muscle contraction; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of smooth muscle contraction; positive regulation of neutrophil degranulation; positive regulation of leukocyte cell-cell adhesion; phosphatidylinositol-mediated signaling; lipopolysaccharide-mediated signaling pathway; cellular response to cAMP; signal transduction; positive regulation of smooth muscle cell proliferation; G protein-coupled purinergic nucleotide receptor signaling pathway; neutrophil degranulation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5724
	19204
	ENSG00000169403
	ENSMUSG00000056529
	P25105
	Q62035
	NM_001164723; NM_000952; NM_001164721; NM_001164722
	NM_001081211
	NP_000943; NP_001158193; NP_001158194; NP_001158195
	NP_001074680
	Wikidata
View/Edit Human	View/Edit Mouse

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is encoded in the human by the PTAFR gene.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM] Its pathogenetic role in chronic kidney failure has also been reported recently.