Prostaglandin EP3 receptor

PTGER3
Identifiers
Aliases	PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3, lnc003875
External IDs	OMIM: 176806; MGI: 97795; HomoloGene: 105703; GeneCards: PTGER3; OMA:PTGER3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	71,047,816 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	157,351,525 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; human kidney; ; body of uterus; ; renal medulla; ; Skeletal muscle tissue of rectus abdominis; ; tail of epididymis; ; myometrium; ; vena cava; ; Epithelium of choroid plexus; ; adipose tissue;
	Top expressed in
	tunica adventitia of aorta; ; lumbar spinal ganglion; ; right kidney; ; barrel cortex; ; brown adipose tissue; ; white adipose tissue; ; subcutaneous adipose tissue; ; tunica media of zone of aorta; ; seminal vesicula; ; intercostal muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; prostaglandin receptor activity; signal transducer activity; prostaglandin E receptor activity; protein binding;
Cellular component	nuclear envelope; membrane; plasma membrane; integral component of plasma membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of fever generation; cell death; signal transduction; negative regulation of gastric acid secretion; phospholipase C-activating G protein-coupled receptor signaling pathway; intestine smooth muscle contraction; inflammatory response; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	5733
	19218
	ENSG00000050628
	ENSMUSG00000040016
	P43115
	P30557
NM_000957; NM_001126044; NM_198712; NM_198713; NM_198714;
	NM_198715; NM_198716; NM_198717; NM_198718; NM_198719; NM_198720
	NM_011196; NM_001359745
NP_001119516; NP_942007; NP_942008; NP_942009; NP_942010;
	NP_942011; NP_942012
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin EP₃ receptor (EP₃, 53kDa), is a prostaglandin receptor for prostaglandin E₂ (PGE₂) encoded by the human gene PTGER3; it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₄, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological and pathological responses.