MPGES-2

PTGES2
Identifiers
Aliases	PTGES2, C9orf15, GBF-1, GBF1, PGES2, mPGES-2, prostaglandin E synthase 2
External IDs	OMIM: 608152; MGI: 1917592; HomoloGene: 11819; GeneCards: PTGES2; OMA:PTGES2 - orthologs
EC number	5.3.99.3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,128,462 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,295,784 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; mucosa of transverse colon; ; left ventricle; ; right auricle of heart; ; right frontal lobe; ; prefrontal cortex; ; anterior cingulate cortex; ; muscle of thigh; ; left adrenal gland;
	Top expressed in
	right kidney; ; muscle of thigh; ; proximal tubule; ; brown adipose tissue; ; granulocyte; ; neural layer of retina; ; soleus muscle; ; masseter muscle; ; dentate gyrus of hippocampal formation granule cell; ; interventricular septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity; DNA binding; glutathione binding; isomerase activity; protein binding; heme binding; lyase activity; electron transfer activity; prostaglandin-E synthase activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; Golgi membrane; mitochondrion; perinuclear region of cytoplasm; nucleus; extracellular region; cytosol; azurophil granule lumen;
Biological process	prostaglandin metabolic process; lipid metabolism; cell redox homeostasis; fatty acid metabolic process; secretion; positive regulation of transcription, DNA-templated; fatty acid biosynthetic process; prostaglandin biosynthetic process; cyclooxygenase pathway; neutrophil degranulation; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	80142
	96979
	ENSG00000148334
	ENSMUSG00000026820
	Q9H7Z7
	Q8BWM0
	NM_001256335; NM_025072; NM_198938; NM_198939; NM_198940
	NM_133783
	NP_001243264; NP_079348; NP_945176
	NP_598544
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal prostaglandin E synthase-2 (mPGES-2) or Prostaglandin E synthase 2 is an enzyme that in humans encoded by the PTGES2 gene located on chromosome 9. The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.