Prostacyclin receptor

PTGIR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F8K
Identifiers
Aliases	PTGIR, IP, PRIPR, prostaglandin I2 (prostacyclin) receptor (IP), prostaglandin I2 receptor
External IDs	OMIM: 600022; MGI: 99535; HomoloGene: 7496; GeneCards: PTGIR; OMA:PTGIR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,625,089 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,644,830 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; Descending thoracic aorta; ; right coronary artery; ; left coronary artery; ; upper lobe of left lung; ; monocyte; ; tibial arteries; ; apex of heart; ; right auricle of heart; ; right lung;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; blood; ; trigeminal ganglion; ; ankle; ; intercostal muscle; ; mesenteric lymph nodes; ; embryo; ; endothelial cell of lymphatic vessel; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; guanyl-nucleotide exchange factor activity; prostacyclin receptor activity;
Cellular component	integral component of membrane; cytosol; plasma membrane; integral component of plasma membrane; membrane;
Biological process	negative regulation of platelet-derived growth factor receptor signaling pathway; cell-cell signaling; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; response to lipopolysaccharide; negative regulation of smooth muscle cell proliferation; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway; inflammatory response; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	5739
	19222
	ENSG00000160013
	ENSMUSG00000043017
	P43119
	P43252
	NM_000960
	NM_008967
	NP_000951
	NP_032993
	Wikidata
View/Edit Human	View/Edit Mouse

The prostacyclin receptor, also termed the prostaglandin I₂ receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed prostaglandin I₂, PGI₂, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene. While possessing many functions as defined in animal model studies, the major clinical relevancy of IP is as a powerful vasodilator: stimulators of IP are used to treat severe and even life-threatening diseases involving pathological vasoconstriction.