Prostacyclin synthase

PTGIS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B6H, 2IAG
Identifiers
Aliases	PTGIS, CYP8, CYP8A1, PGIS, PTGI, prostaglandin I2 (prostacyclin) synthase, prostaglandin I2 synthase
External IDs	OMIM: 601699; MGI: 1097156; HomoloGene: 37374; GeneCards: PTGIS; OMA:PTGIS - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,568,137 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; right coronary artery; ; saphenous vein; ; pericardium; ; left uterine tube; ; Descending thoracic aorta; ; ascending aorta; ; germinal epithelium; ; left coronary artery; ; vena cava;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; isomerase activity; metal ion binding; monooxygenase activity; protein binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; prostaglandin-I synthase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; caveola; nucleus; endoplasmic reticulum; extracellular space;
Biological process	prostaglandin metabolic process; positive regulation of execution phase of apoptosis; cellular response to interleukin-6; lipid metabolism; icosanoid metabolic process; cyclooxygenase pathway; fatty acid metabolic process; positive regulation of angiogenesis; fatty acid biosynthetic process; negative regulation of nitric oxide biosynthetic process; decidualization; cellular response to interleukin-1; positive regulation of peroxisome proliferator activated receptor signaling pathway; apoptotic signaling pathway; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; cellular response to hypoxia; embryo implantation; prostaglandin biosynthetic process; NAD biosynthesis via nicotinamide riboside salvage pathway;
	Sources:Amigo / QuickGO
Orthologs
	5740
	19223
	ENSG00000124212
	n/a
	Q16647
	O35074
	NM_000961
	NM_008968
	NP_000952
	NP_032994
	Wikidata
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prostaglandin-I synthase
prostaglandin-I synthase
	Cartoon diagram of human prostacyclin synthase. Heme group visible at center. From PDB: 2IAG
Identifiers
EC no.	5.3.99.4
CAS no.	65802-86-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 isomerases.