PTPN1

PTPN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F, 1G7G, 1GFY, 1I57, 1JF7, 1KAK, 1KAV, 1L8G, 1LQF, 1NL9, 1NNY, 1NO6, 1NWE, 1NWL, 1NZ7, 1OEM, 1OEO, 1OES, 1OET, 1OEV, 1ONY, 1ONZ, 1PA1, 1PH0, 1PTT, 1PTU, 1PTV, 1PTY, 1PXH, 1PYN, 1Q1M, 1Q6J, 1Q6M, 1Q6N, 1Q6P, 1Q6S, 1Q6T, 1QXK, 1SUG, 1T48, 1T49, 1T4J, 1WAX, 1XBO, 2AZR, 2B07, 2B4S, 2BGD, 2BGE, 2CM2, 2CM3, 2CM7, 2CM8, 2CMA, 2CMB, 2CMC, 2CNE, 2CNF, 2CNG, 2CNH, 2CNI, 2F6F, 2F6T, 2F6V, 2F6W, 2F6Y, 2F6Z, 2F70, 2F71, 2FJM, 2FJN, 2H4G, 2H4K, 2HB1, 2HNP, 2HNQ, 2NT7, 2NTA, 2QBP, 2QBQ, 2QBR, 2QBS, 2VEU, 2VEV, 2VEW, 2VEX, 2VEY, 2ZMM, 2ZN7, 3A5J, 3A5K, 3CWE, 3D9C, 3EAX, 3EB1, 3EU0, 3I7Z, 3I80, 3QKP, 3QKQ, 3SME, 3ZMP, 3ZMQ, 3ZV2, 4BJO, 4I8N, 4QAH, 4QAP, 4QBE, 4QBW, 4Y14, 4ZRT
Identifiers
Aliases	PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1
External IDs	OMIM: 176885; MGI: 97805; HomoloGene: 2119; GeneCards: PTPN1; OMA:PTPN1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	50,585,241 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,821,305 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; right lung; ; spleen; ; appendix; ; monocyte; ; lymph node; ; granulocyte; ; tibial arteries; ; ascending aorta; ; left adrenal gland;
	Top expressed in
	tibiofemoral joint; ; corneal stroma; ; Rostral migratory stream; ; granulocyte; ; mesenteric lymph nodes; ; stroma of bone marrow; ; spleen; ; Ileal epithelium; ; decidua; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; insulin receptor binding; phosphatase activity; ephrin receptor binding; receptor tyrosine kinase binding; zinc ion binding; protein binding; protein tyrosine phosphatase activity; protein phosphatase 2A binding; enzyme binding; hydrolase activity; protein kinase binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; plasma membrane; early endosome; endoplasmic reticulum; cytoplasmic side of endoplasmic reticulum membrane; sorting endosome; cytoplasmic vesicle; protein-containing complex;
Biological process	regulation of endocytosis; actin cytoskeleton reorganization; insulin receptor signaling pathway; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein tyrosine kinase activity; protein dephosphorylation; regulation of hepatocyte growth factor receptor signaling pathway; response to endoplasmic reticulum stress; endoplasmic reticulum unfolded protein response; regulation of intracellular protein transport; positive regulation of IRE1-mediated unfolded protein response; negative regulation of insulin receptor signaling pathway; IRE1-mediated unfolded protein response; regulation of type I interferon-mediated signaling pathway; regulation of signal transduction; negative regulation of MAP kinase activity; positive regulation of receptor catabolic process; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; negative regulation of PERK-mediated unfolded protein response; regulation of insulin receptor signaling pathway; platelet-derived growth factor receptor-beta signaling pathway; dephosphorylation; negative regulation of signal transduction; Unfolded Protein Response;
	Sources:Amigo / QuickGO
Orthologs
	5770
	19246
	ENSG00000196396
	ENSMUSG00000027540
	P18031
	P35821
	NM_002827; NM_001278618
	NM_011201
	NP_001265547; NP_002818
	NP_035331
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.