PTPN12

PTPN12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5J8R
Identifiers
Aliases	PTPN12, PTP-PEST, PTPG1, protein tyrosine phosphatase, non-receptor type 12, protein tyrosine phosphatase non-receptor type 12
External IDs	OMIM: 600079; MGI: 104673; HomoloGene: 37691; GeneCards: PTPN12; OMA:PTPN12 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	77,640,069 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	21,055,911 bp
RNA expression pattern
	Top expressed in
	gonad; ; epithelium of colon; ; monocyte; ; right lung; ; tibial nerve; ; Achilles tendon; ; lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; subcutaneous adipose tissue;
	Top expressed in
	tail of embryo; ; Gonadal ridge; ; left lung lobe; ; genital tubercle; ; stroma of bone marrow; ; trigeminal ganglion; ; abdominal wall; ; otic placode; ; hair follicle; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; phosphatase activity; protein binding; hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity;
Cellular component	podosome; cell junction; cell projection; focal adhesion; cytoplasm; cytosol; nucleoplasm;
Biological process	tissue regeneration; dephosphorylation; protein dephosphorylation; regulation of epidermal growth factor receptor signaling pathway; peptidyl-tyrosine dephosphorylation; cellular response to epidermal growth factor stimulus; ERBB2 signaling pathway; negative regulation of ERBB signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5782
	19248
	ENSG00000127947
	ENSMUSG00000028771
	Q05209
	P35831
	NM_001131008; NM_001131009; NM_002835
	NM_011203; NM_001356590; NM_001356591; NM_001356592
	NP_001124480; NP_001124481; NP_002826
	NP_035333; NP_001343519; NP_001343520; NP_001343521
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein–protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.