PTPN18

PTPN18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OC3, 4GFU, 4GFV, 4NND
Identifiers
Aliases	PTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18
External IDs	OMIM: 606587; MGI: 108410; HomoloGene: 74971; GeneCards: PTPN18; OMA:PTPN18 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	130,375,405 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,514,814 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right uterine tube; ; mucosa of transverse colon; ; rectum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; spleen; ; tendon of biceps brachii; ; body of pancreas;
	Top expressed in
	granulocyte; ; thymus; ; blood; ; spleen; ; mesenteric lymph nodes; ; submandibular gland; ; tibiofemoral joint; ; duodenum; ; lacrimal gland; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; cytoplasm; cytosol; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; ERBB2 signaling pathway; negative regulation of ERBB signaling pathway; cellular response to cytokine stimulus; blastocyst formation;
	Sources:Amigo / QuickGO
Orthologs
	26469
	19253
	ENSG00000072135
	ENSMUSG00000026126
	Q99952
	Q61152
	NM_001142370; NM_014369
	NM_011206
	NP_001135842; NP_055184
	NP_035336
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.