PTPN3

PTPN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B49, 4QUM, 4QUN, 4RH5, 4RH9, 4RHG, 4RI4, 4RI5, 4S0G
Identifiers
Aliases	PTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
External IDs	OMIM: 176877; MGI: 105307; HomoloGene: 74451; GeneCards: PTPN3; OMA:PTPN3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	109,498,313 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	57,301,837 bp
RNA expression pattern
	Top expressed in
	oocyte; ; Skeletal muscle tissue of rectus abdominis; ; secondary oocyte; ; triceps brachii muscle; ; glutes; ; muscle of thigh; ; thoracic diaphragm; ; lateral nuclear group of thalamus; ; gastrocnemius muscle; ; biceps brachii;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; trigeminal ganglion; ; ankle; ; otolith organ; ; utricle; ; soleus muscle; ; tibialis anterior muscle; ; olfactory system;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; phosphoprotein phosphatase activity; phosphatase activity; phosphotyrosine residue binding; ATPase binding; cytoskeletal protein binding; protein binding; protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	cytoplasm; membrane; cytoplasmic side of plasma membrane; cytoskeleton; plasma membrane;
Biological process	regulation of membrane depolarization during action potential; protein dephosphorylation; liver regeneration; regulation of sodium ion transmembrane transporter activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; dephosphorylation; peptidyl-tyrosine dephosphorylation; negative regulation of epidermal growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5774
	545622
	ENSG00000070159
	ENSMUSG00000038764
	P26045
	A2ALK8
NM_001145368; NM_001145369; NM_001145370; NM_001145371; NM_001145372;
	NM_002829
	NM_011207; NM_001384115
NP_001138840; NP_001138841; NP_001138842; NP_001138843; NP_001138844;
	NP_002820
	NP_035337; NP_001371044
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.