PTPN5

PTPN5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BIJ, 2BV5, 2CJZ
Identifiers
Aliases	PTPN5, PTPSTEP, STEP, STEP61, protein tyrosine phosphatase, non-receptor type 5, protein tyrosine phosphatase non-receptor type 5
External IDs	OMIM: 176879; MGI: 97807; HomoloGene: 8423; GeneCards: PTPN5; OMA:PTPN5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,792,721 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,783,432 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; nucleus accumbens; ; putamen; ; primary visual cortex; ; caudate nucleus; ; external globus pallidus; ; superior frontal gyrus; ; postcentral gyrus;
	Top expressed in
	olfactory tubercle; ; superior frontal gyrus; ; nucleus accumbens; ; lateral septal nucleus; ; globus pallidus; ; primary visual cortex; ; anterior amygdaloid area; ; nucleus of stria terminalis; ; medial dorsal nucleus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; phosphotyrosine residue binding; protein binding; protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	84867
	19259
	ENSG00000110786
	ENSMUSG00000030854
	P54829
	P54830
NM_001039970; NM_001278236; NM_001278238; NM_001278239; NM_006906;
	NM_032781
	NM_001163565; NM_013643
NP_001035059; NP_001265165; NP_001265167; NP_001265168; NP_008837;
	NP_116170
	NP_001157037; NP_038671
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase non-receptor type 5 is an enzyme that in humans is encoded by the PTPN5 gene.

Protein tyrosine phosphatase (PTP), non-receptor type 5, also known as STEP (STriatal-Enriched protein tyrosine Phosphatase), was the first brain-specific PTP discovered. The human STEP locus maps to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5. The single STEP gene is alternatively spliced to produce several isoforms, the best characterized of which are the cytosolic STEP₄₆ protein and the membrane-associated STEP₆₁ protein.