PTPRC

PTPRC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YGU, 1YGR, 5FMV, 5FN6, 5FN7
Identifiers
Aliases	PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
External IDs	OMIM: 151460; MGI: 97810; HomoloGene: 2126; GeneCards: PTPRC; OMA:PTPRC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	198,757,476 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	138,103,446 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; blood; ; epithelium of nasopharynx; ; granulocyte; ; lymph node; ; bone marrow; ; bone marrow cells; ; thymus; ; spleen;
	Top expressed in
	granulocyte; ; spleen; ; thymus; ; tibiofemoral joint; ; stroma of bone marrow; ; submandibular gland; ; blood; ; right lung; ; Paneth cell; ; mesenteric lymph nodes;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; hydrolase activity; protein tyrosine phosphatase activity;
Cellular component	integral component of membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; membrane raft; extracellular exosome; external side of plasma membrane; secretory granule membrane;
Biological process	B cell receptor signaling pathway; cell cycle phase transition; release of sequestered calcium ion into cytosol; negative regulation of protein kinase activity; bone marrow development; stem cell development; protein dephosphorylation; negative regulation of cytokine-mediated signaling pathway; positive regulation of hematopoietic stem cell migration; regulation of cell cycle; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of T cell mediated cytotoxicity; cell surface receptor signaling pathway; B cell proliferation; T cell differentiation; positive regulation of B cell proliferation; defense response to virus; positive regulation of T cell proliferation; hematopoietic progenitor cell differentiation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; positive regulation of stem cell proliferation; dephosphorylation; positive regulation of protein kinase activity; peptidyl-tyrosine dephosphorylation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5788
	19264
	ENSG00000081237; ENSG00000262418
	ENSMUSG00000026395
	P08575
	P06800
	NM_001267798; NM_002838; NM_080921; NM_080922
	NM_001111316; NM_001268286; NM_011210
	NP_001254727; NP_002829; NP_563578; NP_563578.2; NP_002829.3
	NP_001104786; NP_001255215; NP_035340
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).

PTPRC is a critical enzyme involved in regulating immune cell function. PTPRC is a transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells, particularly lymphocytes. It plays a key role in the activation and differentiation of T cells, B cells, and other immune cells by modulating signaling pathways. It functions by dephosphorylating specific tyrosine residues on target proteins, thereby controlling various signaling processes essential for immune response and homeostasis.