PTPRG

PTPRG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H4V, 2HY3, 2NLK, 2PBN, 3JXH, 3QCB, 3QCC, 3QCD, 3QCE, 3QCF, 3QCG, 3QCH, 3QCI, 3QCJ, 3QCK, 3QCL, 3QCM, 3QCN
Identifiers
Aliases	PTPRG, HPTPG, PTPG, R-PTP-GAMMA, RPTPG, protein tyrosine phosphatase, receptor type G, protein tyrosine phosphatase receptor type G
External IDs	OMIM: 176886; MGI: 97814; HomoloGene: 2129; GeneCards: PTPRG; OMA:PTPRG - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	62,297,609 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; lower lobe of lung; ; caput epididymis; ; synovial joint; ; buccal mucosa cell; ; oocyte; ; pericardium; ; corpus epididymis; ; urethra; ; stromal cell of endometrium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity; identical protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane; extracellular space;
Biological process	regulation of homophilic cell adhesion; protein dephosphorylation; negative regulation of epithelial cell migration; transmembrane receptor protein tyrosine kinase signaling pathway; dephosphorylation; brain development; negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5793
	19270
	ENSG00000144724
	n/a
	P23470
	Q05909
	NM_002841; NM_001375471
	NM_008981; NM_001347593
	NP_002832; NP_001362400
	NP_001334522; NP_033007
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.