PTPRK

PTPRK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C7S
Identifiers
Aliases	PTPRK, R-PTP-kappa, protein tyrosine phosphatase, receptor type K, protein tyrosine phosphatase receptor type K
External IDs	OMIM: 602545; MGI: 103310; HomoloGene: 55693; GeneCards: PTPRK; OMA:PTPRK - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	128,520,616 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	28,473,393 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; epithelium of colon; ; gallbladder; ; duodenum; ; Achilles tendon; ; superior frontal gyrus; ; islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; stomach;
	Top expressed in
	tail of embryo; ; genital tubercle; ; barrel cortex; ; Paneth cell; ; ciliary body; ; right kidney; ; iris; ; Region I of hippocampus proper; ; epithelium of lens; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; phosphoprotein phosphatase activity; gamma-catenin binding; phosphatase activity; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein kinase binding; hydrolase activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; adherens junction; photoreceptor outer segment; integral component of plasma membrane; cell surface; axon; soma; dendrite; leading edge membrane; plasma membrane; cell junction; intracellular membrane-bounded organelle;
Biological process	negative regulation of keratinocyte proliferation; cellular response to UV; protein dephosphorylation; negative regulation of cell cycle; cellular response to reactive oxygen species; focal adhesion assembly; cell adhesion; negative regulation of cell migration; protein localization to cell surface; negative regulation of transcription, DNA-templated; neuron projection development; transforming growth factor beta receptor signaling pathway; cell migration; signal transduction; negative regulation of cell population proliferation; dephosphorylation; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5796
	19272
	ENSG00000152894; ENSG00000273993
	ENSMUSG00000019889
	Q15262
	P35822
NM_001135648; NM_001291981; NM_001291982; NM_001291983; NM_001291984;
	NM_002844
	NM_008983; NM_001359355; NM_001359356
NP_001129120; NP_001278910; NP_001278911; NP_001278912; NP_001278913;
	NP_002835
	NP_033009; NP_001346284; NP_001346285
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene. PTPRK is also known as PTPkappa and PTPκ.