PTPRO

PTPRO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDs	OMIM: 600579; MGI: 1097152; HomoloGene: 21564; GeneCards: PTPRO; OMA:PTPRO - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	15,602,175 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	137,440,231 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; rectum; ; ganglionic eminence; ; middle temporal gyrus; ; human kidney; ; ventricular zone; ; nucleus accumbens; ; prefrontal cortex; ; mucosa of transverse colon;
	Top expressed in
	renal corpuscle; ; arcuate nucleus; ; median eminence; ; olfactory bulb; ; barrel cortex; ; ventromedial nucleus; ; piriform cortex; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; protein homodimerization activity; phosphatase activity; Wnt-protein binding; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; growth cone; plasma membrane; dendritic spine; integral component of plasma membrane; axon; apical plasma membrane; neuron projection; extracellular exosome; lamellipodium; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of cell-substrate adhesion; negative regulation of neuron projection development; monocyte chemotaxis; negative regulation of retinal ganglion cell axon guidance; regulation of glomerular filtration; slit diaphragm assembly; protein dephosphorylation; glomerulus development; axon guidance; cell morphogenesis; glomerular visceral epithelial cell differentiation; peptidyl-tyrosine dephosphorylation; negative regulation of glomerular filtration; negative regulation of canonical Wnt signaling pathway; lamellipodium assembly; dephosphorylation; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	5800
	19277
	ENSG00000151490
	ENSMUSG00000030223
	Q16827
	E9Q612
NM_002848; NM_030667; NM_030668; NM_030669; NM_030670;
	NM_030671
	NM_001164401; NM_001164402; NM_001164403; NM_011216
NP_002839; NP_109592; NP_109593; NP_109594; NP_109595;
	NP_109596
	NP_001157873; NP_001157874; NP_001157875; NP_035346
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.