PTPRT

PTPRT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OOQ
Identifiers
Aliases	PTPRT, RPTPrho, protein tyrosine phosphatase, receptor type T, protein tyrosine phosphatase receptor type T, RPTP-rho, R-PTP-T
External IDs	OMIM: 608712; MGI: 1321152; HomoloGene: 56924; GeneCards: PTPRT; OMA:PTPRT - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	43,189,970 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	162,503,067 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; middle temporal gyrus; ; Brodmann area 23; ; frontal pole; ; superior frontal gyrus; ; Brodmann area 46; ; primary visual cortex; ; orbitofrontal cortex; ; postcentral gyrus; ; dorsolateral prefrontal cortex;
	Top expressed in
	piriform cortex; ; nucleus of stria terminalis; ; central gray substance of midbrain; ; lumbar spinal ganglion; ; superior frontal gyrus; ; superior colliculus; ; olfactory bulb; ; primary visual cortex; ; dorsal tegmental nucleus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; beta-catenin binding; protein binding; phosphoprotein phosphatase activity; hydrolase activity; alpha-catenin binding; cadherin binding; delta-catenin binding; gamma-catenin binding; transmembrane receptor protein tyrosine phosphatase activity; protein phosphatase binding; protein homodimerization activity; STAT family protein binding;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane; integral component of plasma membrane;
Biological process	protein dephosphorylation; cell adhesion; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; transmembrane receptor protein tyrosine kinase signaling pathway; dephosphorylation; peptidyl-tyrosine dephosphorylation; negative regulation of cell migration; cellular response to interleukin-6; negative regulation of receptor signaling pathway via STAT; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	11122
	19281
	ENSG00000196090
	ENSMUSG00000053141
	O14522
	Q99M80
	NM_007050; NM_133170; NM_001394024; NM_001394025; NM_001394026
	NM_001291149; NM_001291150; NM_001291151; NM_021464
	NP_008981; NP_573400
	NP_001278078; NP_001278079; NP_001278080; NP_067439
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.

PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that are conserved among vertebrates, but in humans show significant distinction from other vertebrates. This region may, therefore, have played a key role in differentiating humans from apes.