PTPRZ1

PTPRZ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JXF, 3S97, 5AWX
Identifiers
Aliases	PTPRZ1, HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z1
External IDs	OMIM: 176891; MGI: 97816; HomoloGene: 2136; GeneCards: PTPRZ1; OMA:PTPRZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	122,062,036 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	23,052,915 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; endothelial cell; ; Amygdala; ; Region I of hippocampus proper; ; optic nerve; ; caudate nucleus; ; nucleus accumbens; ; corpus callosum; ; external globus pallidus;
	Top expressed in
	vestibular membrane of cochlear duct; ; Rostral migratory stream; ; mammillary body; ; median eminence; ; ventromedial nucleus; ; lobe of cerebellum; ; arcuate nucleus; ; cerebellar vermis; ; lateral septal nucleus; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; hydrolase activity; integrin binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; extracellular region; perineuronal net; intrinsic component of plasma membrane; plasma membrane; extracellular matrix; synapse;
Biological process	axonogenesis; protein dephosphorylation; oligodendrocyte differentiation; regulation of oligodendrocyte progenitor proliferation; central nervous system development; hematopoietic progenitor cell differentiation; learning or memory; peptidyl-tyrosine dephosphorylation; dephosphorylation; cytokine-mediated signaling pathway; regulation of myelination; negative regulation of neuron apoptotic process; positive regulation of oligodendrocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5803
	19283
	ENSG00000106278
	ENSMUSG00000068748
	P23471
	B9EKR1
	NM_001206838; NM_001206839; NM_002851; NM_001369395; NM_001369396
	NM_001081306; NM_011219; NM_178180; NM_001311064; NM_001361349
	NP_001193767; NP_001193768; NP_002842
NP_001074775; NP_001297993; NP_001348278; NP_035349; NP_001389981;
	NP_001389982; NP_001389983
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.