PTTG1

PTTG1
Identifiers
Aliases	PTTG1, EAP1, HPTTG, PTTG, TUTR1, pituitary tumor-transforming 1, PTTG1 regulator of sister chromatid separation, securin, ECRAR
External IDs	OMIM: 604147; MGI: 1353578; HomoloGene: 3110; GeneCards: PTTG1; OMA:PTTG1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,428,739 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,317,078 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; left testis; ; ganglionic eminence; ; right testis; ; sperm; ; gingival epithelium; ; trabecular bone; ; bone marrow; ; mucosa of esophagus;
	Top expressed in
	ciliary body; ; secondary oocyte; ; zygote; ; retinal pigment epithelium; ; primary oocyte; ; iris; ; blood; ; primitive streak; ; ankle; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity; DNA-binding transcription factor activity; SH3 domain binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	chromosome segregation; chromosome organization; homologous chromosome segregation; cellular response to DNA damage stimulus; cell division; spermatogenesis; cell cycle; anaphase-promoting complex-dependent catabolic process; DNA repair; regulation of transcription, DNA-templated; negative regulation of peptidase activity; negative regulation of endopeptidase activity; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of mitotic sister chromatid separation; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9232
	30939
	ENSG00000164611
	ENSMUSG00000020415
	O95997; Q6IAL9
	Q9CQJ7
	NM_004219; NM_001282382; NM_001282383
	NM_001131054; NM_013917; NM_001362799
NP_001269311; NP_001269312; NP_004210; NP_001269311.1; NP_001269312.1;
	NP_004210.1
	NP_001124526; NP_038945; NP_001349728
	Wikidata
View/Edit Human	View/Edit Mouse

Securin is a protein that in humans is encoded by the PTTG1 gene.