Paxillin

PXN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O9V, 2VZD, 2VZG, 2VZI, 3GM1, 3PY7, 3U3F, 4EDN, 1OW6, 1OW7, 1OW8, 3RQE, 3RQF, 3RQG, 4XGZ, 4XH2
Identifiers
Aliases	PXN, entrez:5829, paxillin
External IDs	OMIM: 602505; MGI: 108295; HomoloGene: 37697; GeneCards: PXN; OMA:PXN - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,265,771 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,694,046 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; tibial nerve; ; left uterine tube; ; apex of heart; ; gastrocnemius muscle; ; canal of the cervix; ; muscle layer of sigmoid colon; ; upper lobe of left lung; ; body of uterus; ; transverse colon;
	Top expressed in
	granulocyte; ; vestibular membrane of cochlear duct; ; internal carotid artery; ; external carotid artery; ; endothelial cell of lymphatic vessel; ; retinal pigment epithelium; ; right lung lobe; ; left lung; ; tibiofemoral joint; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; vinculin binding; protein-containing complex binding; metal ion binding; integrin binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; neuropilin binding; protein phosphatase binding; transcription coregulator activity;
Cellular component	focal adhesion; plasma membrane; stress fiber; microtubule associated complex; cell junction; cell cortex; cytoskeleton; lamellipodium; cytoplasm; cytosol; adherens junction;
Biological process	muscle contraction; epidermal growth factor receptor signaling pathway; signal complex assembly; cellular response to reactive oxygen species; vascular endothelial growth factor receptor signaling pathway; cell adhesion; growth hormone receptor signaling pathway; cell-matrix adhesion; transforming growth factor beta receptor signaling pathway; signal transduction; response to peptide; endothelial cell migration; positive regulation of stress fiber assembly; substrate adhesion-dependent cell spreading; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	5829
	19303
	ENSG00000089159
	ENSMUSG00000029528
	P49023
	Q8VI36
NM_001080855; NM_001243756; NM_002859; NM_025157; NM_001385981;
	NM_001385982; NM_001385983; NM_001385984; NM_001385985; NM_001385986; NM_001385987; NM_001385988; NM_001385989; NM_001385990
	NM_011223; NM_133915
	NP_001074324; NP_001230685; NP_002850; NP_079433
NP_035353; NP_598676; NP_001389995; NP_001389996; NP_001389997;
	NP_001389998; NP_001389999
	Wikidata
View/Edit Human	View/Edit Mouse

Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.