Pancreatic enzymes (medication)

Pancreatic enzymes, also known as pancreases, pancrelipases or pancreatins are commercial mixtures of amylase, lipase, protease and lactase obtained from pigs. The components are digestive enzymes similar to those normally produced by the human pancreas. They help in the digestion of fats, starches, and proteins. They are used to treat malabsorption syndrome due to certain pancreatic insufficiencies. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long-term pancreatitis, pancreatic cancer, or MODY 5, among others. The preparation is taken by mouth. The treatment is also known as pancreatic enzyme replacement therapy or PERT.

Common side effects include vomiting, abdominal pain, constipation, and diarrhea. Other side effects include perianal irritation and high blood uric acid. Use is believed to be safe during pregnancy.

Pancreatic enzymes have been used as medications since at least the 1800s. They are on the World Health Organization's List of Essential Medicines. In 2022, it was the 253rd most commonly prescribed medication in the United States, with more than one million prescriptions.