Pantoprazole

Pantoprazole
	Above: molecular structure of pantoprazole Below: 3D representation of a pantoprazole molecule
Clinical data
Trade names	Protonix, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601246
License data	US DailyMed: Pantoprazole;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth and intravenous
Drug class	Proton-pump inhibitor
ATC code	A02BC02 (WHO) A02BD04 (WHO) A02BD11 (WHO);
Legal status
Legal status	AU: S4 (Prescription only) / S2; UK: POM (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	77%
Protein binding	98%
Metabolism	Liver (CYP2C19, CYP3A4)
Elimination half-life	1-2 hours
Excretion	Urine, feces
Identifiers
	IUPAC name (RS)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole;
CAS Number	102625-70-7 ;
PubChem CID	4679;
IUPHAR/BPS	7260;
DrugBank	DB00213 ;
ChemSpider	4517 ;
UNII	D8TST4O562;
KEGG	D05353 ;
ChEBI	CHEBI:7915 ;
ChEMBL	ChEMBL1502 ;
CompTox Dashboard (EPA)	DTXSID4023416 ;
ECHA InfoCard	100.111.005
Chemical and physical data
Formula	C16H15F2N3O4S
Molar mass	383.37 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic
	SMILES FC(F)Oc1ccc2[nH]c(nc2c1)S(=O)Cc3nccc(OC)c3OC;
	InChI InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21) ; Key:IQPSEEYGBUAQFF-UHFFFAOYSA-N ;
	(verify)

Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. It may also be used along with other medications to eliminate Helicobacter pylori. Pantoprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It is available by mouth and by injection into a vein.

Common side effects include headaches, diarrhea, abdominal pain, and joint pain. More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency. Use in pregnancy appears to be safe. Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. It works by inactivating (H+/K+)-ATPase function in the stomach.

The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. It is available as a generic medication. In 2022, it was the sixteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions. In Australia, it was one of the top 10 most prescribed medications between 2017 and 2023.